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diagnosis differential nephrology management causes potassium hematology hyperkalemia tls tumor cancer emergencies high oncologic apml barre differentiation encephalopathy gbs gitelman
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
acid, Liddle's Syndrome ... R - Cushing's syndrome ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome ... #nephrology #causes
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... 6L/day) • For hyperkalemia ... wandering_er #Tumor #Lysis ... #Syndrome #TLS ... #oncology #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Syndrome Leukostasis ... hyperviscosity syndrome ... Syndrome: • Pathophysiology ... hydration - Hyperkalemia ... #Syndrome #TLS
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... of breath • Neurologic ... Superior Vena Cava Syndrome ... EMERGENCIES: Tumor Lysis ... Syndrome: • Azotemia
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... #Syndrome #TLS ... #Pathophysiology ... #oncology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
Aldosterone: Cushing syndrome ... 17alpha-hydroxylase deficiency, Syndrome ... excess, Liddle syndrome ... deficiency, Bartter syndrome ... , Gitelman syndrome
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... H+ secretion → Hypokalemia ... dr_missyhanna #Gitelman #Syndrome
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• NSAIDs • ACE ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis ... potassium #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• NSAIDs • ACE ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis ... potassium #high #nephrology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... develop leukostasis syndrome ... & DIC • Tumor lysis ... syndrome: Develops ... Leukemia #Hematology #Oncology
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