32 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... Hypokalemia Metabolic alkalosis ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... - Differential Diagnosis ... , Gitelman Syndrome ... #Differential #Diagnosis ... #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... - Differential Diagnosis ... , Gitelman Syndrome ... #Differential #Diagnosis ... #Algorithm #Nephrology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... - Differential Diagnosis ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... #Differential #Diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology ... #differential #diagnosis
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
Likely Metabolic Alkalosis ... Contraction Urine Cl ... Barter, or Gitelman ... Syndrome Unremarkable ... #algorithm #diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... Rhabdomyolysis Treatment ... #Syndrome #diagnosis ... #nephrology #management ... #pathophysiology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential Diagnosis ... acid, Liddle's Syndrome ... , Gitelman's syndrome ... #Differential #Diagnosis ... #Algorithm #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Differential Diagnosis ... - Metabolic alkalosis ... - Bartter - Gitelman ... #Algorithm #Pathophysiology ... #Nephrology #Chloride
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... tubule Liddle syndrome ... Defects #Kidney #Nephrology ... #Diagnosis #Differential