30 results
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
major sources of ammonia ... production of ammonia ... myeloma, CML, AML ... #Pathophysiology ... Hyperammonemia #Differential
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
#Lactulose #pharmacology ... #mechanism #ammonia ... #hepatology #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology #
Mechanism of Action for Common Diabetes Medications

 • SGLT2i (Dapagliflozin)
 • TZD (Pioglitazone)
 • Biguanides (Metformin)
#Medications #pharmacology ... #pathophysiology ... #endocrinology
Urine Anion Gap in NAGMA
NA + K - Cl = surrogate for Urine NH4+
NH4+ is excreted
NAGMA NA + K - Cl ... excreted with Cl ... negative AG implies ↑ ammonium ... is intact: - All ... NAGMA #diagnosis #differential
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Hyperuricemia - Differential ... Myeloid Leukemia (AML ... drugs • ACE ... Hyperuricemia #Differential ... Diagnosis #Algorithm #endocrinology
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework

Hematologic & Vascular:
 • Multiple myeloma & Acute leukemia (plasma cells
Hyperammonemia - Differential ... Hyperammonemia #ammonia ... #Differential # ... Diagnosis #Pathophysiology
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... vs. 1) • Fewer ACS ... Benefits #SickleCell #pathophysiology ... #pharmacology
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... counterregulatory hormones act ... details of the pathophysiology ... #Pathophysiology ... DKA #Diabetes #Endocrinology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... : - Catch-all term ... range of potential pathophysiologic ... - Pathophysiology ... Targetoid #Algorithm #Differential