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hematology rheumatology apml classification clinical differentiation dislocation edema erythematosus facial injury knee management monoclonal msk nsfw paraproteinemias physicalexam posterior sle
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Hypergammaglobulinemic macular ... Evans • ITP • Cl-NH ... to cold IgG • Lupus ... (Thrombosis in vascular ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... Erythematous, macular ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... La, anti-Jo-1, SCL
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Facial Swelling - Differential ... Diagnosis Framework ... Medications: • ACE ... Trauma: • Ocular ... Myxedema coma Vascular
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Cathepsin G release → vascular ... initiation • Differential ... management #hematology #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis Framework ... inflammation Others: • Lupus ... and bullous or vesicular ... such as systemic lupus ... retinopathy Lab Tests
Posterior Knee Dislocation Injury Specifically, POSTERIOR KNEE DISLOCATIONS can have significant associated injury that needs unique approach
nerve injury (25%) TEST ... Compartment syndrome ... rotation and varus stress ... -->>>> LINK TO ACL ... msk #clinical #video
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