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management hematology hemophagocytic hlh lymphohistiocytosis acidosis activation causes differential elevation hemeonc hepatology hepatorenal hrs lactate lactic macrophage mas nephrology sjogrens
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
thrombocytopenia • Liver ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... lymph node, or liver ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... - Compartment syndrome ... mellitus/DKA - Liver ... gluconeogenesis Liver
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Occurs in advanced liver ... hepatitis, or acute liver ... • Definitive: Liver ... Treat underlying liver ... • Urgent liver
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... vasculitis: 10%-16% Liver ... Adenocarcinoma Treatment ... #Rheumatology # ... Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... search for and treatment ... - Elevated liver ... Treatment Approach ... #Management #Hematology
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