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diagnosis hematology anemia hemolytic clinical differential autoagglutination autoimmune blood hemolysis microscopy path rbc smear aiha algorithm antiglobulin causes cold cutaneous
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Secondary Cold Agglutinin ... Secondary Cold Agglutinin ... anemia • Cold agglutinin
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
hemoglobinuria) • Cold Agglutinin
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
( +/- ) Cold agglutinin
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
cryoglobulinemia, Cold agglutinin
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold agglutinin
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold agglutinin
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Agglutination - Cold agglutinins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. primary cold agglutin
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