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Vasopressors and Inotropes - Pharmacology Summary Vasopressors Phenylephrine (alpha-1) • Increases BP, SVR • Risk of reflex bradycardia
Phenylephrine (alpha ... • Higher doses cause ... more alpha-effect ... Dose dependent receptor ... cAMP/cGMP • Causes
Drug-Induced Urinary Retention Drug-induced urinary retention is very common and can be caused by many classes of
common and can be caused ... by many classes ... both α1 and β3 receptors ... • Opioids • Alpha ... & Beta Receptor
Summary of the therapeutic uses of adrenergic agonists Table of Catecholamine Pressors, Non-Catecholamines, Alpha and Beta Receptor
the therapeutic uses ... Non-Catecholamines, Alpha ... and Beta Receptor ... NonCatecholamines #Receptors ... #Specificity #Alpha
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
cord before the alpha ... neurotransmitter cause ... post-synaptic receptors ... & LMN lesions cause ... This lesion causes
Vasoactive Agents - Receptor Profiles Adrenergic Profile: α → β phenylephrine, norepinephrine, dopamine, epinephrine, dobutamine, isoproterenol - Dr. Rishi
Vasoactive Agents - Receptor ... Vasoactive #Agents #Receptors ... #Profiles #alpha
Adrenergic Receptors - Agonists and Antagonists • Alpha-1 Vascular • Alpha-2 Presynaptic • Beta-1 Heart •
Adrenergic Receptors ... Antagonists • Alpha ... 1 Vascular • Alpha ... #Adrenergic #Receptors
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Note: Receptor binding ... • Dopamine D2 Receptor ... • Serotonin 2A Receptor ... • Serotonin 2C Receptor ... eyes, brain) • alpha1
Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors)
and Autonomic Receptors ... Ach -> Nicotinic Receptor ... -> Muscarinic Receptor ... -> Adrenergic Receptor ... -> Adrenergic Receptor
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Binds to the D2 receptor ... bind to the D2 receptor ... over-stimulating receptors ... Bind to 5-HT 1A receptor ... similar to D2-receptor
Beta Blockers Overview - Beta Adrenergic Antagonists Cardioselective: M - Metoprolol A - Atenolol N - Nebivolol B
Esmolol Mixed alpha ... that we have B1 receptors ... hearts while B2 receptors ... actually are mixed alpha1
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