9 results
Toxic Alcohol Metabolism and Metabolites

#Toxic #Alcohol #Metabolism #Metabolites #Toxicology #Pharmacology
Toxic Alcohol Metabolism ... Metabolites #Toxic #Alcohol ... #Metabolism #Metabolites ... #Toxicology #Pharmacology
Metabolic Pathways of Toxic Alcohols 

Panel A shows the metabolic pathways of toxic alcohols. Alcohol dehydrogenase
Metabolic Pathways ... Panel A shows the metabolic ... important target for antidotal ... As metabolism proceeds ... Pathophysiology #Toxicology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion ... Syndrome (PRIS) ... Hyperlactatemia • Metabolic ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Insufficiency Metabolic ... Myasthenia Gravis Pharmacologic ... Alcohol) • Drug ... Chronic Fatigue Syndrome
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Radiation • Metabolic ... Paraneoplastic syndrome ... Hypothyroid • Metabolic ... Statins, amiodarone, Alcohol
Disulfiram Mechanism of action :
the oxidation of alcohol ... acetaldehyde stage during alcohol ... metabolism following ... Blurred vision, Confusion ... Anxiety) #pharmacology
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Propofol infusion ... syndrome (PRIS) ... Versed) - CYP3A4 metabolism ... No pharmacologic ... (Haldol) - No pharmacologic
Toxic Alcohol Ingestion: Methanol
Solvent found in cleaning and printing solutions, adhesives, stains, paint removers,
antifreeze agent in
Toxic Alcohol Ingestion ... gasoline additive Pharmacology ... 1-2 mL/kg - Metabolite ... Diagnosis #Management #Toxicology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
Respiratory Distress Syndrome ... Hemolysis, DIC Metabolic ... : Metabolic acidosis ... Colchicine #Toxicity #Toxicology ... #Phases #Pharmacology