10 results
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Antibiotics as Antidotes ... Valproic Acid Toxicity ... #Antibiotics #Antidotes ... #Toxicology #Pharmacology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion ... Hyperlactatemia • Metabolic ... Propofol #Related #Infusion ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
at anytime if toxicity ... Theophylline - For i/v infusion ... - Continuous infusion ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... - Metabolism - ... #Clozapine #Toxicology ... #Toxicity #Diagnosis ... #Pharmacology
Tramadol - Toxicology
Due to different CYP-2D6 genotypes, people variably metabolize tramadol into its active metabolite, M1
This
Tramadol - Toxicology ... people variably metabolize ... #Tramadol #Toxicology ... #Toxicity #Diagnosis ... #Pharmacology
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... Acute toxicity ... alkalosis and metabolic ... Chronic toxicity ... #Toxicology #Pharmacology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
of Colchicine Toxicity ... : Metabolic acidosis ... #Colchicine #Toxicity ... #Toxicology #Phases ... #Pharmacology #
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Propofol infusion ... glycol (solvent) toxicity ... Versed) - CYP3A4 metabolism ... No pharmacologic ... (Haldol) - No pharmacologic
Toxic Alcohol Ingestion: Methanol
Solvent found in cleaning and printing solutions, adhesives, stains, paint removers,
antifreeze agent in
gasoline additive Pharmacology ... 1-2 mL/kg - Metabolite ... formic acid) causes toxicity ... Diagnosis #Management #Toxicology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... evidence of marrow toxicity ... Methotrexate #Leucovorin #Antidote ... #Toxicology #Toxicity ... #Management #Pharmacology