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Direct-acting oral anticoagulants (DOACs) for VTE treatment and prevention - Comparison Table

#DOAC #Anticoagulants #Anticoagulation #VTE #Management
anticoagulants (DOACs ... ) for VTE treatment ... #DOAC #Anticoagulants ... VTE #Management #Pharmacology ... #Comparison #Table
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... transfusion as needed Antidotes ... concentrate - If antidotes ... hematology #management #pharmacology
Table 3. Antidotes that may be used in cardiac arrest (The A to P of treatment
Table 3. ... Antidotes that may ... (The A to P of treatment ... #Management #Toxicology ... #Antidotes #Cardiac
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... DOACs are substrates ... #Interactions #Table ... #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... interruption per treatment ... table ... Perioperative #Management #Treatment ... #pharmacology #
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
vary depending on treatment ... Therapeutic #Ranges #Toxicology ... #Pharmacology # ... Diagnosis #Table
Summary of actions of some Cholinergic Agonists

Bethanechol 
• Used in treatment of urinary retention 
• Binds
Bethanechol • Used in treatment ... • Used as an antidote ... • Used as an antidote ... Cholinergic #Agonists #Pharmacology ... #Table #Summary
In addition to management of ABCs, exposure to nerve gases requires antidotes. There are 3 important
gases requires antidotes ... #Management #Toxicology ... #NerveAgents #Treatment ... #Table
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... (folinic acid) treatment ... Methotrexate #Leucovorin #Antidote ... #Toxicology #Toxicity ... #Management #Pharmacology