342 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
coagulation #coumadin #heparin ... #warfarin #apaxiban
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
clotting #INR #heparin ... rivaroxaban #Xarelto #apixaban
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Heparin, Fondaparinux ... Unfractionated heparin ... molecular weight heparin ... smaller average heparin ... DOAC #Dabigatran #Apixaban
Coagulation Cascade - Actions of Anticoagulants
 • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin
 • Fondaparinux
 • Direct
Anticoagulants • Heparin ... Unfractionated heparin ... : Rivaroxaban, Apixaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Warfarin - 100% Hepatic ... , 0% Renal Apixaban ... - 75% Hepatic, ... Dabigatran - 20% Hepatic ... Edoxaban - 50% Hepatic
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
PCC (Kcentra) - Heparin ... (Praxbind) - Apixaban
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Molecular Weight Heparin ... Xa inhibitors - Apixaban
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
- Rivaroxaban; apixaban ... edoxaban; VKA • Hepatic ... Gl bleed - VKA, apixaban
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Thrombin Time, Ecarin ... Rivaroxaban Apixaban
Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa 
 - Interaction
Heparin and Low ... Molecular Weight Heparin ... antithrombin with heparin ... Unfractionated heparin ... factor Xa #Heparin