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diagnosis hematology differential algorithm coagulation disease druginduced lupus neurology oncology rheumatology anemia aplastic b12 bleeding bruising cardiology cardiomyopathy chagas classification
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PTT • Prolonged ... PTT • Prolonged ... PTT, Normal PT ... • Prolonged PTT ... #coagulation #disorders
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Perform a PTT mixing ... PT/NORMAL PTT: ... PT/ABNORMAL PTT
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... Treat primary cause ... INR < 2.3 - APTT ... #treatment #management
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
inherited bleeding disorder ... type 2B) • Normal ... PT/INR • Normal ... aPTT (prolonged ... factor VIII) Treatment
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... may be normal in ... mild cases) •
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
Ketosis Disorders ... IVF or PO): The pt ... Glucosuria causes ... differential #diagnosis #management ... #endocrinology
Management of Hyponatremia Hypertonic Saline - Only indicated if patient has severe symptoms + Na < 125 Give
Management of Hyponatremia ... SIADH — look for cause ... hourly • Identify Cause ... give specific treatment ... #algorithm #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
anti-MPO - Seen with PTU ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... rheumatology #diagnosis #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... positive in 2/3 of pts ... limb or joint disorders ... #treatment #neurology
Pheochromocytoma - Diagnosis and Management Summary 10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
malignant, pediatric cases ... and Signs: 50% pts ... hypertension; some normal ... leukocytosis, psychiatric disorders ... #treatment
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