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hematology differential treatment coagulation disorders activation algorithm blanching bruise dic disease disseminated ecchymosis hematomas hemophilia hemostasis inr intravascular ketones ketosis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... PTT • Prolonged ... PTT • Prolonged ... Differential #Diagnosis
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Clinical • Easy bruising ... • Prolonged ... INR • Normal aPTT ... (prolonged if very ... VonWillebrand #Disease #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #Coagulation #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... /ABNORMAL PTT: ... Perform a PTT mixing ... /NORMAL PTT: Suggests ... /ABNORMAL PTT:
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... normal in mild cases
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... Excessive bruising ... & prolonged bleeding ... to be normal, PT ... Diagnosis VWF
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... ketoacidosis (DKA) - caused ... Glucosuria causes ... #differential #diagnosis ... #management #endocrinology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
manifestations: from easy bruising ... purpura to mucosal bleeding ... ↑ PTT • ↑ Fibrin ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Pheochromocytoma - Diagnosis and Management Summary 10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
Pheochromocytoma - Diagnosis ... malignant, pediatric cases ... and Signs: 50% pts ... , induction of anesthesia ... adrenoceptors, potentially leading
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