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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... (DIC) c. ... #Causes #diagnosis
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
(DIC) Platelet ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
== NORMAL PT ... level NORMAL PT ... /ABNORMAL PTT: ... Perform a PTT mixing ... ABNORMAL PTT: Prolongation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... #Diagnosis #Honc ... Intravascular #Coagulation
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
and Management ... • Oxytocin 40 IU ... epinephrine prn DIC ... CBC, fibrinogen, PT ... /PTT • Treat with