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hematology differential causes abnormal disseminated intravascular algorithm laboratory treatment bleeding bruising disorders hemophilia hemorrhage hemostasis honc inr isth laboratoryfindings labs
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PTT • Prolonged ... PTT • Prolonged ... PTT, Normal PT ... PTT, Normal PT ... Differential #Diagnosis
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
PT - Prolonged ... aPTT and Prolonged ... PT - Prolonged ... aPTT Dr. ... #Abnormal #APTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
and/or aPTT Prolonged ... PT and aPTT 1. ... (DIC) c. ... #aPTT #Prolonged ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
PT/PTT • Low ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #diagnosis #causes
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... aPTT are both prolonged ... #Abnormal #PT ... #aPTT #Prolonged
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
(DIC) Platelet ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
== NORMAL PT ... /ABNORMAL PTT: ... Perform a PTT mixing ... prolonged after ... ABNORMAL PTT: Prolongation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... #Diagnosis #Honc ... Intravascular #Coagulation
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... mild cases) • PT
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
and Management ... • Oxytocin 40 IU ... epinephrine prn DIC ... CBC, fibrinogen, PT ... /PTT • Treat with
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