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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Coagulation (DIC ... /PTT • Low plasma ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... causes #treatment #management
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
for Disseminated Intravascular ... Coagulation (DIC ... , aPTT: • Expected ... small vessels #DIC ... diagnosis #hematology #laboratory
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
and/or aPTT Prolonged ... typically prolong aPTT ... and aPTT 1. ... Disseminated intravascular ... coagulation (DIC
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC ... #Disseminated #Intravascular ... #Coagulation #Labs
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... PTT suggests liver ... , disseminated intravascular