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diagnosis treatment coagulation heparin rheumatology activation aflp algorithm anticoagulant anticoagulation apixaban cascade causes clot dabigatran dic differential disseminated edoxaban fatty
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... /aPTT normal • ... Differential #Diagnosis #Management ... #Algorithm #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... protein C and S Pathophysiology ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
PT and/or aPTT) ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... Chronic Management ... #treatment #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin #clot #PT ... #PTT #diagnosis ... #models #hematology ... #pathophysiology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... Cr, ↓Glucose, ↓PLT ... Liver #Pregnancy #hepatology ... obgyn #diagnosis #management ... #pathophysiology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Diagnosis and Management ... ♀, ↑Age, ESRD Pathophysiology ... heparin-PF4 complex → plt ... hypercoagulable state and plt ... #Treatment #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Cytopenia +++ (Plt ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
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