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diagnosis hematology differential workup abnormal bleeding bruising calcium coagulation dic disorders disseminated hemostasis hypercalcemia hypertension indications intravascular management mixing platelet
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... or APTT Artifactually ... to identify the cause ... of Prolonged APTT ... #hematology #evaluation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... fibrinogen • Elevated ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... : INR/PT, aPTT(liver ... (CVID, WAS), (neurologic ... - Bone marrow evaluation ... patients if the cause
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /NORMAL PTT: Suggests ... prolonged after ... and the PTT suggests ... discern these causes
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... 1) Clinical clues ... 2) PTH - Frankly ... differential #diagnosis #endocrinology ... #calcium #elevated
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... be performed PT ... , PTT, and fibrinogen ... Normal or slightly elevated ... or may not be elevated
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Approach (when evaluation ... heart failure, neurologic ... Vasculitis • Endocrinologic ... apnea: CPAP, most pts ... Neurologic disorders
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