18 results
Fantastic handout on anticoagulation by Dr. Jessie Donato, superstar medical educator and hospitalist at ⁦@ClevelandClinic⁩ ⁦@CCF_IMCHIEFS⁩

#Anticoagulation
Fantastic handout on anticoagulation ... CCF_IMCHIEFS⁩ #Anticoagulation ... #HeparinDrip #gtt ... #Algorithm #PTT ... #Monitoring #Management
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... Disseminated intravascular ... #Abnormal #PT
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Anticoagulants #Tests #Anticoagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... vessels #DIC #Disseminated
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
== NORMAL PT ... /ABNORMAL PTT: ... Perform a PTT mixing ... /ABNORMAL PTT: ... liver failure, disseminated
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... LaboratoryFindings #Disseminated
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... Chronic Management