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hematology coagulation treatment anticoagulant apixaban cascade causes clinical dabigatran dic differential disseminated edoxaban gsv hemophilia hemorrhage heparin inhibitor intravascular macrophage
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
platelet #thrombin #clot ... #PT #PTT #diagnosis ... pathophysiology #anticoagulation
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... mixing study (aPTT ... may be normal in ... mild cases) • PT
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... #Syndrome #Diagnosis ... #Management #Hematology
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
- Differential Diagnosis ... and Management ... over 10 minutes, may ... CBC, fibrinogen, PT ... /PTT • Treat with
Greater Saphenous Vein Thrombosis on POCUS Pt-leg pain/redness/swelling. Proximal TRV image. Diagnosis: Greater Saphenous Vein Thrombosis without
Thrombosis on POCUS Pt-leg ... Diagnosis: Greater ... or prior hx of clots ... be treated with anticoagulation ... , otherwise it may
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