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hematology coagulation differential dic disseminated treatment abnormal bleeding bruising disorders hemophilia hemostasis isth ketones ketosis prolonged scoring thromboticthrombocytopenicpurpura ttp workup
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Prothrombin Time (PT ... typically prolong PT ... Disseminated intravascular ... #Causes #diagnosis
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/ABNORMAL PTT: ... Perform a PTT mixing ... /ABNORMAL PTT: ... , disseminated intravascular ... discern these causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity is the diagnostic ... be performed PT ... , PTT, and fibrinogen ... reflection of intravascular
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... ketoacidosis (DKA) - caused ... Glucosuria causes ... #differential #diagnosis ... #management #endocrinology
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