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hematology rheumatology differential druginduced lupus activation coagulation comparison dic dil disease disorders disseminated fusarium hemophilia hemorrhage infections infectiousdiseases intravascular ketones
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #causes #treatment
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
GI. uterine) Laboratory ... 2B) • Normal PT ... INR • Normal aPTT ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von ... #Management #treatment
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity is the diagnostic ... available for rapid diagnosis ... be performed PT ... , PTT, and fibrinogen
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
- Differential Diagnosis ... and Management ... CBC, fibrinogen, PT ... /PTT • Treat with ... unresponsive to usual treatment
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... ketoacidosis (DKA) - caused ... Glucosuria causes ... #differential #diagnosis ... #management #endocrinology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... anti-MPO - Seen with PTU ... Discontinuation of causal ... #rheumatology #diagnosis ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
calcium-b) • Laboratory ... anti-MPO - Seen with PTU ... Discontinuation of causal ... #rheumatology #diagnosis ... #treatment #management
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
BCx+ in -40% of cases ... disease: • Optimal treatment ... . open globe), pt ... infectiousdiseases #diagnosis ... #management
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