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diagnosis hematology causes coagulation platelet treatment activation aggregometry algorithm bruising dic disease disseminated hemepath hemophilia hemorrhage hemostasis intravascular ketones ketosis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PT (INR), Prolonged ... PT (INR), Normal ... PTT, Normal PT ... (INR) - Bleeding ... #PT #INR #Differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
== NORMAL PT ... level NORMAL PT ... /ABNORMAL PTT: ... /NORMAL PTT: Suggests ... /ABNORMAL PTT:
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
disorder Clinical ... thrombocytopenia in ... 2B) • Normal PT ... /INR • Normal ... aPTT (prolonged
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... < 2.3 - APTT
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... - History of bleeding ... epistaxis, gingival bleeding ... : INR/PT, aPTT(liver ... #Differential #
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... Chronic Management
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage - Differential ... Diagnosis and Management ... CBC, fibrinogen, PT ... /PTT • Treat with ... compression (using ultrasound
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
Ketosis Disorders ... IVF or PO): The pt ... #ketones #differential ... #diagnosis #management ... #endocrinology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... Normal platelet, PT ... , PTT (diff from ... could also be seen in ... #Platelet #disorders
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... purpura to mucosal bleeding ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Syndrome #Diagnosis #Management
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