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diagnosis differential hematology coagulation treatment abnormal fusarium infections infectiousdiseases prolonged algorithm bleeding bruising chest dic disorders hemophilia hemorrhage hemostasis intravascular
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Prothrombin Time (PT ... typically prolong PT ... Disseminated intravascular ... #Abnormal #PT
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
life-threatening causes ... EKG • Bedside ultrasound ... , LET, lipase, PT ... . aPTT • Serial
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /NORMAL PTT: Suggests ... and the PTT suggests ... liver failure, disseminated ... discern these causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
Diagnosis and Management ... CBC, fibrinogen, PT ... /PTT • Treat with ... compression (using ultrasound ... Differential #Diagnosis #Management
Ketosis Disorders Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... ketoacidosis (DKA) - caused ... Glucosuria causes ... differential #diagnosis #management ... #endocrinology
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
germinates > blood > disseminated ... BCx+ in -40% of cases ... Sino-pulmonary, Disseminated ... . open globe), pt ... infectiousdiseases #diagnosis #management
Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to
Therapeutic options for disseminated ... amphotericin B for severe cases ... . open globe), pt ... infectiousdiseases #management
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