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differential hematology treatment coagulation infectiousdiseases abnormal infections prolonged algorithm aspergillus bleeding bruising chest dic disorders fungal hemophilia hemorrhage hemostasis ia
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Prothrombin Time (PT ... typically prolong PT ... Disseminated intravascular ... #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
Chest Pain - Diagnosis ... life-threatening causes ... EKG • Bedside ultrasound ... , LET, lipase, PT ... . aPTT • Serial
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /NORMAL PTT: Suggests ... and the PTT suggests ... liver failure, disseminated ... discern these causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
and Management ... infections are caused ... Gastrointestinal, Disseminated ... positive with Histo, Fusarium ... #Management #treatment
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
Fusarium Infections ... germinates > blood > disseminated ... . open globe), pt ... infectiousdiseases #diagnosis ... #management
Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to
Fusarium Treatment ... Therapeutic options for disseminated ... amphotericin B for severe cases ... . open globe), pt ... infectiousdiseases #management
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
- Differential Diagnosis ... and Management ... CBC, fibrinogen, PT ... /PTT • Treat with ... compression (using ultrasound
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