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coagulation hematology differential causes intravascular abnormal prolonged bleeding bruising hemorrhage hemostasis honc isth laboratory laboratoryfindings labs obgyn obstetrics postpartum scoring
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... Disseminated intravascular ... coagulation (DIC ... #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... #Diagnosis #Honc ... #Disseminated #
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
== NORMAL PT ... /ABNORMAL PTT: ... Perform a PTT mixing ... ABNORMAL PTT: Prolongation ... failure, disseminated
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
and Management ... epinephrine prn DIC ... CBC, fibrinogen, PT ... /PTT • Treat with ... compression (using ultrasound
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