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diagnosis hematology oncology algorithm approach arthritis bloodcell calculation classification erythematosus folicacid gap globulin hodgkins homocysteine index joint leukemia lupus lymphocytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Vitamin B12 or Folate ... Bite Cell RBC: G6PD ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... reticulocyte count is elevated ... of the initial work-up ... #VitaminB12 #Folate ... #AAFP
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... , Vitamin B12, Folate ... , Intrinsic RBC ... defects (e.g. sickle cell ... #anemia #differential
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... Elevated LDH 5. ... Elevated beta 2 ... Leukemia #diagnosis #workup
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Send for cell count ... = Worry about late ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... syndrome • Erythema elevatum ... +Organomegaly+↑RBC ... (-) hemolytic anemia ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... sediment, and elevated ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Elevated Globulin ... Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... anemia • Other ... Gap #ProteinGap #differential
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