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diagnosis hematology differential oncology causes generalized secondary bloodcell chronic classification cll hodgkins leukemia lymphocytic macrocytic management microcytic microscopy monoclonal morphology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... IgM associated lymphoma ... disease, Malignant lymphoma ... differential #diagnosis #hematology ... #microscopy #atlas
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... renal failure/uremia ... Hyperthyroidism CBC ... Differential: • Lymphoma ... #generalized #dermatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... acute blood loss, hemolysis ... Algorithm by Dr. ... #Workup #Hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
renal failure/uremia ... Hyperthyroidism CBC ... Differential: • Lymphoma ... #secondary #systemic ... #generalized #dermatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... • Pruritis ... nodosum • Immune hemolytic ... anemia • Pain ... Workup: • Full
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Metastatic cancer, Lymphoma
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Marginal zone lymphoma ... +Organomegaly+↑RBC ... • Coombs (-) hemolytic ... anemia due to cold
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Lymphocytosis on CBC ... ’s CLL Scoring system ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
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