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diagnosis differential rheumatology hematology lupus oncology sle algorithm approach bloodcell causes classification cll comparison diffuse disease druginduced gap globulin joint
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... iron deficiency anemia ... myeloma Rouleaux: Chronic ... Multiple myeloma, Chronic ... hematology #microscopy #atlas
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Systemic Lupus Erythematosus ... • Rheumatoid Arthritis ... (Pancytopenia, WBC ... Age > 50 • Chronic ... Lymphocytic Leukemia (CBC
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... lung syndrome Arthritis ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... with Lupus: • Chronic
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
rheumatic fever • Chronic ... Lyme), reactive arthritis ... hepatitis, herpes • Chronic ... SLE, psoriatic arthritis ... rheumatology #approach #workup
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Systemic lupus erythematosus ... the presence of anemia ... Screening Tests for Chronic ... #laboratory #workup
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... • Immunologic Workup ... Systemic Lupus Erythematosus ... • Immunologic Workup ... • Evolution: Chronic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... and often causes arthritis ... ischemia - Skin: erythematous ... systemic lupus erythematosus ... Lab Tests: • CBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphocytosis on CBC ... • Neutropenia, anemia ... leukemia #CLL #Chronic ... Leukemia #diagnosis #workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... (RA, Temporal arteritis ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell anemia
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