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diagnosis hematology differential algorithm chronic leukemia lymphocytic management blood cell classification gap globulin hemeonc hemolytic hodgkins markers microscopy nomenclature plasmacytoma
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Unstable hemoglobin disorders ... Diseases #Red #BloodCell ... #RBC #Morphology ... hematology #microscopy #atlas
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
, Auer rod • Lymphoid ... - Abnormal morphology ... Pelger-Huet, Macrocytic anemia ... (CLL) - CD38(new ... bcr-able (+) ↑ WBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... other reproducible morphologic ... membrane disorder ... Diagnosis #Algorithm #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... classification #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... leukemia in adults • Disorder ... 5) Symptoms of anemia ... lymphoma (Richter ... Lymphocytic #Leukemia #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... Connective tissue disorders ... • Hematology: Lymphoma ... anemia • Other
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... • No CRAB - no anemia ... • Non-Hodgkin Lymphoma ... #Plasmacytoma #Oncology ... #Diagnosis #Workup
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