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diagnosis differential oncology algorithm pancytopenia chronic cll disorders emergencies gap hemeonc infections infectiousdiseases leukemia lymphocytic management mds mycobacteria myelodysplasia myelodysplastic
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... #Aplastic #Anemia ... #oncology #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Eating disorders ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... Primary hematological ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Eating disorders ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... Primary hematological ... Diagnosis #Algorithm #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... changes), high MCV anemia ... unclear, or if a primary ... #Workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Anemia • Aplastic ... Workup: • Complete ... Treatment: Goals: Treating ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... Pure red cell aplasia ... increase in gamma globulins ... Leukemia #diagnosis #workup ... #oncology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... : • Syndrome of ... • Primarily occurs ... Hematologic malignancy ... Bone Marrow - Anemia
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... ): - Hematologic ... Treat underlying cause ... sticky” cells; WBC
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