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diagnosis differential causes algorithm hematology management pathophysiology endocrinology clinical anemia nephrology neurology treatment iron signs symptoms rheumatology workup nutrition physicalexam
Autoimmune Gastritis - Pathophysiology Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
CD4+ T Cells, Autoantibodies ... Pathophysiology #b12 #deficiency
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
of Vitamin B12 Deficiency ... with vitamin B12 deficiency ... develop vitamin B12 deficiency ... • Deficient intrinsic ... parietal cells by autoantibodies
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... small intestine), autoantibodies ... B12 #Cobalamin #Deficiency
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
titers of adrenal autoantibodies ... distinguish between ACTH deficiency ... pituitary) and deficiency
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
to 50X ULN • Autoantibodies ... to 50X ULN • Autoantibodies ... : >50X ULN • Autoantibodies ... to 10x ULN • Autoantibodies
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Sclerosis Associated Autoantibodies ... Systemic #Sclerosis #Autoantibodies
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... disease • Prolidase deficiency
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... to diagnosis deficiency ... levels will be deficient ... accumulate in B12 deficiency ... tests for B12 deficiency
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... RheumOnePagers #Autoantibodies
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Goodpasture's syndrome #Autoantibodies
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