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diagnosis hematology cardiology classification differential mds myelodysplastic syndrome anthracycline approach bacilliformis bartonella cardiotoxicity celiac chemotherapy chronic cll cobalamin coccidioides coccidioidomycosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... Deficiency • B12 ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... anemia Treatment ... #Anemia #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology ... #oncology
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
- Diagnosis Algorithm ... Iron-deficiency anemia ... unresponsive to treatment ... without discernable cause ... #gastroenterology
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
, Anemia • Prevalence ... Crohn's > UC Anemia ... fatigue despite disease ... /other causes • ... #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... wt loss • If anemia ... to IBD, celiac disease ... Check for IF ab Treatment ... Deficiency #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Anemia • Aplastic ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... diagnosis #hematology #oncology
Treatment of Stable Narrow-Complex Tachycardia Regular Rhythm: • Attempt vagal maneuvers • Give adenosine 6 milligrams IV
Treatment of Stable ... Treat underlying cause ... Treat underlying cause ... #management #cardiology ... #algorithm
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment ... #oncology #hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Fever Hematologic disease ... caused by Bartonella ... severe hemolytic anemia ... TREATMENT: ​• Acute ... Fever #diagnosis #management
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