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diagnosis differential anemia aplastic causes chronic dermatology emergencies hemeonc lymphocytic management mds myelodysplasia myelodysplastic nonpalpable oncologic petechiae purpural purpuric rash
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... Significant ↓ PLT: Petechiae ... infiltrates (anemia, thrombocytopenia ... ) CLL Symptoms: ... #Hematology #Oncology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Rashes- THE ALGORITHMIC ... ; however, an algorithmic ... Figure 4, page 12 ... While all patients ... #Diagnosis #Dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Leukemia, Tumour ... Megakaryopoiesis • B12 ... ITP • SLE • CLL ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... Neutropenia, anemia, thrombocytopenia ... leukemia #CLL ... #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... caused by bleeding (petechiae ... Nutritional: vitamin B12 ... Syndromes #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... bleeding, and petechiae ... virus (EBV) • Leukemia ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... syndrome): - Hematologic ... Usually myeloid leukemias ... ± tocilizumab; call
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