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diagnosis hematology algorithm cobalamin macrocytic elevatedmcv management vitamin aafp acidosis approach dementia elevation fat fatigue fatrbc folate folicacid geriatrics homocysteine
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
the most likely cause ... recovery also causes ... of the initial work-up ... deficiency. ... #VitaminB12 #Folate
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... • Dietary Deficiency ... #Macrocytosis #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... (>100 fL) • B12 ... #MCV #Classification
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Reticulocytes, MCV ... • B12/Folate ... #Classification ... Diagnosis #Algorithm #Causes
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Celiac disease, IBD ... Stomach: Pernicious anemia ... #differential #
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... #differential # ... diagnosis #causes
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... ) - Differential ... RBC>13 • Iron Deficiency ... #Macrocytosis # ... elevatedMCV #Differential
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... If persistent macrocytosis ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes •
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... antagonists #VitaminB12 ... #cobalamin #differential
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... diarrhea related to IBD ... hypersegmented neutrophils, macrocytosis ... #Cobalamin #Deficiency
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