14 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Corpuscular Volume (MCV ... ) - Differential ... • Dietary Deficiency ... - Low Serum B12 ... #Macrocytosis #
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach ... to Anemia - Differential ... • B12/Folate ... #Classification ... #Approach #Differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... ) - Differential ... Diagnosis Algorithm Low ... (>100 fL) • B12 ... #MCV #Classification
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
(Morphological Approach ... - MCV) Low MCV ... Megaloblastic: Vitamin B12 ... deficiency • ... #differential #
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... inflammation) • Iron deficiency ... , B12 deficiency ... #Differential #
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Approach to Hypoproliferative ... • 812, Folate ... Deficiency • ... #differential # ... algorithm #hematology #workup
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased Heme Synthesis or
with Low Mean Corpuscular ... Differential Diagnosis ... RBC>13 • Iron Deficiency ... #Macrocytosis # ... elevatedMCV #Differential
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... hypersegmented neutrophils, macrocytosis ... - Low Vit B12 ... #Cobalamin #Deficiency ... #diagnosis #management
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
Crohn's > UC Anemia ... If persistent macrocytosis ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... Algorithm #diagnosis #management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... may result from low ... hematology #diagnosis #management