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diagnosis hematology algorithm macrocytosis mcv oncology aafp acidosis approach cobalamin crrt dementia elevatedmcv elevation fatigue folate folicacid geriatrics hodgkins homocysteine
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... #Anemia #differential ... algorithm #hematology #workup
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... and Folate Deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... morphologic #mcv #differential ... #diagnosis #causes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... deficiency.
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... (>100 fL) • B12 ... #MCV #Classification ... #Differential #
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... • B12/Folate ... Deficiency • Aplastic ... #Classification ... Diagnosis #Algorithm #Causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... : • Worsening macrocytic ... #Cobalamin #Deficiency ... #diagnosis #management
Major neurocognitive disorders (MNCD): Diagnosis and workup 1) Clinical diagnosis Cognitive impairment + loss of autonomy 2)
Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... MNCD #Dementia #Differential ... #Subtypes #Classification
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes • ... Algorithm #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Nutritional: vitamin B12 ... Workup: • Complete ... blood count with differential
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