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Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
evaluation of macrocytic ... B12 deficiency ... deficiency. ... #Macrocytosis #Macrocytic ... #Anemia #VitaminB12
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin ... B12 deficiency, ... morphologic #mcv #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... RBC: Pyridoxine deficiency ... (sometimes) Macrocytic ... RBC: Vitamin B12 ... RBC #Morphology #differential
Causes of Low Vitamin B12 Levels
Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people
Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... antagonists #VitaminB12 ... #cobalamin #differential
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
Syndrome - Thiamine Deficiency ... longstanding thiamine (vitamin ... B1) deficiency, ... and retrograde amnesia ... #vitaminB1 #B1 #
FAT RBC Mnemonic for Causes of Macrocytic Anemia
(MCV > 100)

F - Folate (Fetus) and B12 Deficiency
FAT RBC Mnemonic ... Folate (Fetus) and B12 ... Deficiency - Impairs ... released from marrow as ... #Anemia #Differential
Etiologies of Vitamin B12 Deficiency
 • Inadequate intake - Rare but seen in very strict vegans
B12 Deficiency ... B12 deficiency. ... B12 deficiency. ... #VitaminB12 #deficiency ... #differential #
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
common cytopenia: Macrocytic ... • Nutritional: vitamin ... B12 or folic acid ... deficiency • Exposure ... blood count with differential