16 results
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic ... Anemia812 ... , Folate Deficiency ... #Anemia #differential ... algorithm #hematology #workup
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Volume (MCV) - Differential ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... and Folate Deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... morphologic #mcv #differential ... #diagnosis #causes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... deficiency.
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Celiac disease, IBD ... Stomach: Pernicious anemia ... #differential #
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... report dehydration as ... /other causes
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... : • Worsening macrocytic ... diarrhea related to IBD ... #Cobalamin #Deficiency
Altered Mental Status - Differential Diagnosis
 • Neurologic: Stroke, Cerebral hypoxia, Cerebral hemorrhage, Seizure, Trauma, TBI,
Mental Status - Differential ... Diagnosis • Neurologic ... Hypercarbia, Vitamin deficiency ... Mental #Status #AMS ... Diagnosis #Causes
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness - Differential ... valves, COPD, ILD ... , OSA, pHTN, Anemia ... #Diagnosis #causes ... #neurology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Nutritional: vitamin B12 ... Workup: • Complete ... blood count with differential