9 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Approach to Hypoproliferative ... • 812, Folate ... Deficiency • ... #differential # ... diagnosis #algorithm #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Platelet Count - Differential ... Acute hemolysis, deficiency ... anemia, Rebound ... #Platelets #Differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... , B12 deficiency ... MCV #Algorithm #Differential ... #Diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach ... to Anemia - Differential ... • B12/Folate ... #Differential # ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... #Diagnosis #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
(Morphological Approach ... Megaloblastic: Vitamin B12 ... deficiency • ... morphologic #mcv #differential ... diagnosis #causes #hematology
Etiologies of Vitamin B12 Deficiency
 • Inadequate intake - Rare but seen in very strict vegans
deficiency. ... autoantibodies (pernicious anemia ... #differential # ... diagnosis #hematology ... #nutrition
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... blood count with differential ... Syndromes #diagnosis #hematology