15 results
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... turnover • Iron, B-12 ... , or folate deficiency ... Hypertriglyceridemia • Uremia ... • Hemolytic anemia
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
of macrocytic anemia ... elevated, but anemia ... an elevation in ... megaloblastic anemia ... Macrocytosis #Macrocytic #Anemia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
• Metabolic / Nutritional ... : DiabetesB12 deficiency ... , Uremia/ESRD, Hypothyroidism ... differential #diagnosis #causes ... #neurology
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... autoantibodies (pernicious anemia ... Worsening macrocytic anemia ... wt loss • If anemia ... - CBC, PBS - anemia
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Clinical Presentation ... and petechiae Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic ... eliminated • Elevation
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... , Anemia • Prevalence ... Crohn's > UC Anemia ... restricted diet/deficiency ... /other causes
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
Inhibited Pathway caused ... use of N2O can cause ... deficiency. ... The classic clinical ... of pernicious anemia
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... malignancy, or thiamine deficiency ... Elevation Type ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency