11 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• Pernicious anemia ... /B12 deficiency ... mineralization Symptoms ... respiratory failure • Neurologic ... ) - Waddling gait
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... dysfunction, and/or disorders ... intrinsic factor, IF) Clinical ... parasthesias, gait
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
Spinal Cord Disorders ... neurological lesion: Clinical ... of injury • Gait ... Causes: 1. ... myelopathy - Vit B12
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
: CHF, valves, COPD ... ILD, OSA, pHTN, Anemia ... ), NMJ disorder ... Differential #Diagnosis #causes ... #neurology
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... HIV) - Vitamin B12 ... , Copper deficiency ... Lower motor neuron symptoms ... Upper motor neuron symptoms
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... & Fe Sucrose > alt ... restricted diet/deficiency ... symptoms even if ... /other causes
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Bilateral signs and/or symptoms ... • Infectious causes ... • Nutritional Deficiency ... diagnosis #management #neurology
Evaluation of Recurrent Falls

Core Concept:
Maintaining an upright posture requires the integrated function of multiple systems.
Disruption in
embolism - Severe anemia ... presyncope, exertional symptoms ... e.g., diabetic, B12 ... deficiency) ... - Spinal cord disorders
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
experience some symptoms ... a decrease in all ... well as varying clinical ... that involves disorders ... These causes could
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... caused by blood ... age 70 years Symptoms ... Nutritional: vitamin B12 ... or folic acid deficiency