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diagnosis hematology management algorithm cord differential spinal spinalcord alkaline aplastic cobalamin disorders endocrinology hepatology hyophosphatasia hypothyroid hypothyroidism ibd latent lesions
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
despite clinical ... & Fe Sucrose > alt ... restricted diet/deficiency ... symptoms even if ... /other causes •
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... : • Fever • Fatigue ... and petechiae Causes ... • Improve the symptoms ... #oncology #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• Pernicious anemia ... /B12 deficiency ... mineralization Symptoms ... ) - Waddling gait ... Phosphatase: • Other causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... slowing, neuropathy, fatigue ... parasthesias, gait
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... : • Fatigue • ... Nutritional: vitamin B12 ... or folic acid deficiency ... diagnosis #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... : • Fatigue, weight ... - infiltrates (anemia ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Myoedema in Hypothyroidism on Physical Exam Hypothyroidism is a clinical syndrome resulting from the production, secretion or
syndrome resulting ... hormone in almost all ... drowsiness, weight gain ... reflex hammer, caused ... #video #neurology
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 Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... HIV) - Vitamin B12 ... , Copper deficiency ... Lower motor neuron symptoms ... Upper motor neuron symptoms
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... of injury • Gait ... Non-compressive Spinal Cord Causes ... myelopathy - Vit B12 ... MCTD, Sjogren syndrome
The Stages of Syphilis Primary Syphilis - The chancre lesion is the hallmark of primary syphilis.
soles in 50% of cases ... exposure to or symptoms ... tabes dorsalis, gait ... similar to those of B12 ... deficiency.
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