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differential hematology management syndromes classification geriatrics hepatology oncology pathophysiology acidosis acute aki algorithm alkaline alp aplastic bcnie beriberi bloodculture cirrhosis
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... and Sjögren's syndrome ... #low #cobalamin ... #differential #diagnosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
Vitamin B12 (Cobalamin ... • Common Causes ... intrinsic factor, IF) Clinical ... #Cobalamin #Deficiency ... #nutrition
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Differential Diagnosis ... • Dietary Deficiency ... - Low Serum B12 ... Myelodysplastic Syndromes
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... #differential #diagnosis ... signs #symptoms #nutrition
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... Approach - MCV) Low ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... #causes #hematology
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
• Metabolic / Nutritional ... : DiabetesB12 deficiency ... Paraprotein-associated (POEMS syndrome ... #differential #diagnosis ... #causes #neurology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Platelet Disorders • Nutritional ... : vitamin B12 or ... Workup: • Complete ... #diagnosis #hematology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... severe clinical ... • Vitamin D deficiency ... , K, Mg2+) • Slow ... #Diagnosis #Pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... may result from low ... oncology #hematology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... /B12 deficiency ... Phosphatase: • Other causes
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