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Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Wernicke-Korsakoff syndrome ... #differential #diagnosis ... #signs #symptoms ... #nutrition
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
of Copper Deficiency ... diarrhoea, Short bowel syndrome ... Haematological: Anaemia ... #diagnosis #signs ... #riskfactors #symptoms
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
- Diagnosis and ... treatment can improve symptoms ... development of Korsakoff syndrome ... (chronic B1 deficiency ... #neurology #nutrition
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
• Metabolic / Nutritional ... : DiabetesB12 deficiency ... Paraprotein-associated (POEMS syndrome ... #differential #diagnosis ... #causes #neurology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... to IBD, celiac disease ... , alcohol use, symptoms ... #nutrition
Korsakoff Syndrome Clinical Findings: • Confabulation: Usually initial phase of the disease • Anterograde amnesia: Memory impairment
Clinical Findings ... initial phase of the disease ... • Anterograde amnesia ... presentation of Thiamine deficiency ... #neurology #diagnosis
Major neurocognitive disorders (MNCD): Diagnosis and workup 1) Clinical diagnosis Cognitive impairment + loss of autonomy 2)
1) Clinical diagnosis ... Whipple, vitamin deficiency ... - Progressive amnesia ... Aphaso-apraxo-agnosia syndrome ... (parkinsonian signs
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... may cause severe clinical ... due to chronic disease ... overload) Other Symptoms ... #Diagnosis #Pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... • Improve the symptoms ... oncology #hematology #diagnosis
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