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diagnosis differential hematology algorithm management vitaminb12 macrocytosis bariatric bypass classification deficiencies elevatedmcv folicacid gastric hepatology homocysteine macrocytic mma nutrient oncology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
and Vitamin Deficiency ... paraesthesiae • Folate ... B12 - Anaemia, ... #Deficiency #differential ... signs #symptoms #nutrition
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Microcytic" • Iron ... Megaloblastic: Vitamin ... B12 deficiency, ... Folate deficiency ... differential #diagnosis #causes
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... (>100 fL) • B12 ... Folate Deficiency ... #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Algorithm - Iron ... deficiency anemia ... kidney disease - Vitamin ... B12 and/or folate ... deficiency -
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes, MCV ... Iron, Ferritin, ... B12/Folate Deficiency ... Diagnosis #Algorithm #Causes ... #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron ... deficiency • ... Megaloblastic: Folate ... deficiency, B12 ... Differential #Diagnosis #hematology
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
• Thiamine - Nausea ... cardiomyopathy) • Folate ... • Vitamin B12 ... Trace Minerals: • Iron ... #nutrition #table
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin ... B12 • Folate deficiency
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... • Dietary Deficiency ... and Folate Deficiency ... #Hematology
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Diagnosing Vitamin ... B12 and/or Folate ... or folate is simply ... Since folate is ... #Nutrition #Hematology
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