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differential hematology algorithm causes macrocytic management mcv vitaminb12 workup classification elevatedmcv folicacid homocysteine mma pancytopenia vitamin aafp approach ascorbicacid atlas
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Neutrophils - Low RBC Folate ... • Dietary Deficiency ... and Folate Deficiency ... #Macrocytosis #
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Diagnostic Algorithm ... - Iron deficiency ... disease - Vitamin B12 ... and/or folate deficiency ... #diagnosis #differential
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Diagnosing Vitamin ... B12 and/or Folate ... inadequate to diagnosis ... #Deficiency #Diagnosis ... #Nutrition #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Volume (<80 fL) • Iron ... (>100 fL) • B12 ... Folate Deficiency ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... inflammation) • Iron ... Megaloblastic: Folate ... deficiency, B12 ... #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
- Differential Diagnosis ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... MCH, MCHC, Serum Iron ... Reticulocytes • Iron ... Deficiency • ... B12/Folate Deficiency
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
patients with macrocytosis ... deficiency is present ... deficiency. ... #Diagnosis #Macrocytosis ... #VitaminB12 #Folate
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... • Folate deficiency ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... Microcytic" • Iron ... Megaloblastic: Vitamin B12 ... deficiency, Folate ... #causes #hematology
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