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diagnosis hematology differential algorithm causes classification aplastic approach elevatedmcv macrocytic macrocytosis management monoclonal morphologic pancytopenia paraproteinemias
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron deficiency ... Megaloblastic: Folate ... deficiency, B12 ... deficiency, Orotic ... Differential #Diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Microcytic" • Iron deficiency ... Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... diagnosis #causes #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... (>100 fL) • B12 ... Folate Deficiency ... #MCV #Classification ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes, MCV ... Reticulocytes • Iron Deficiency ... • B12/Folate ... Deficiency • Aplastic ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Corpuscular Volume (MCV ... Neutrophils - Low RBC Folate ... • Dietary Deficiency ... and Folate Deficiency ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Diseases: • Systemic lupus ... consumption • Vitamin B12 ... • Folate deficiency
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... • Parvovirus B19 ... #oncology #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... (-) hemolytic anemia ... to cold IgG • Lupus ... Differential #Diagnosis #Oncology
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