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diagnosis differential algorithm causes pancytopenia approach comparisontable erythematosus folate homocysteine management mcv mds mma myelodysplasia myelodysplastic nephritis nephrology neutropenia oncology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined ... Algorithm #Causes #Hematology
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... deficiency. ... deficiency. ... #VitaminB12 #Folate ... #Nutrition #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
(>100 fL) • B12 ... Deficiency • ... Folate Deficiency ... #MCV #Classification ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes • Iron Deficiency ... • B12/Folate ... Deficiency • Aplastic ... #Classification ... Algorithm #Causes #Hematology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
deficiency. ... autoantibodies (pernicious anemia ... #VitaminB12 #deficiency ... differential #diagnosis #hematology ... #nutrition
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
severity (ISN/RPS classification ... 0.5-0.7 g/g by 12 ... months Classification ... treatment #management #rheumatology ... #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Non-autoimmune rheumatologic ... disease • Prolidase deficiency ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology
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