11 results
Methylmalonic Acid and Homocysteine Levels in Vitamin B12 and Folate Deficiency
 • B12 Deficiency: MMA elevated,
B12 Deficiency ... : MMA elevated, ... #MMA #folate #deficiency ... #VitaminB12 #diagnosis ... #hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
red blood cell; MMA ... deficiency is present ... deficiency. ... #VitaminB12 #Folate ... #FolicAcid #MMA
Diagnosing Vitamin B12 and/or Folate Deficiency

It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... deficiency. ... #VitaminB12 #Folate ... #Nutrition #Hematology ... ComparisonTable #MMA
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Diseases: • Systemic lupus ... consumption • Vitamin B12 ... • Folate deficiency
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SEROSITIS - RENAL - NEUROLOGIC ... - HEMOLYTIC ANEMIA ... LEUKOPENIA (<4000/MM3 ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
(DITMA) - TMA ... crisis • Severe B12 ... deficiency • Mechanical ... macroangiopathic hemolytic anemia ... differential #diagnosis #hematology
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
thiamine (vitamin B1 ... ) deficiency, commonly ... and retrograde amnesia ... #vitaminB1 #B1 # ... diagnosis #comparison #neurology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... • Parvovirus B19 ... #oncology #hematology
Etiologies of Vitamin B12 Deficiency
 • Inadequate intake - Rare but seen in very strict vegans
Deficiency • Inadequate ... deficiency. ... autoantibodies (pernicious anemia ... #VitaminB12 #deficiency ... differential #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
et diutinum Neurologic ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology